Endometriosis and Fertility

Dr. Natalie Crawford discusses endometriosis and the best fertility treatments if you have endo. Endometriosis is relatively common in the infertility population. This episode also includes what endometriosis is, difficulties with diagnosis, and the physiology of the disease.

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Natalie answers your social media questions during her segment FFS—For Fertility’s Sake.

Would you do a different embryo transfer protocol for luteal phase defect?

How long after a hysteroscopy can you do an FET?

Do uterine polyps need to be removed?

What are the natural or medicated FET success rates?

I am 39.5, is there a big difference between freezing embryos now and waiting until I’m 40?

What are your thoughts on estrogen priming for a more gradual growth of follicles during IVF?

Don't forget to ask your questions on Instagram for next week’s For Fertility’s Sake segment when you see the question box on Natalie’s page @nataliecrawfordmd. You can also ask a question by calling in and leaving a voicemail. Call 657–229–3672 and ask your fertility question today!     

If you haven’t already, please rate, review, and follow the podcast to be notified of new episodes every Sunday. Plus, be sure to follow along on Instagram @nataliecrawfordmd, check out Natalie's YouTube channel Natalie Crawford MD, and if you're interested in becoming a patient, check out Fora Fertility.


Resources cited:

Lee D, Kim SK, Lee JR, Jee BC. Management of endometriosis-related infertility: Considerations and treatment options. Clin Exp Reprod Med. 2020 Mar;47(1):1-11. doi: 10.5653/cerm.2019.02971. Epub 2020 Feb 24. Erratum in: Clin Exp Reprod Med. 2020 Jun;47(2):153. PMID: 32088944; PMCID: PMC7127898.

Bishop LA, Gunn J, Jahandideh S, Devine K, Decherney AH, Hill MJ. Endometriosis does not impact live-birth rates in frozen embryo transfers of euploid blastocysts. Fertil Steril. 2021 Feb;115(2):416-422. doi: 10.1016/j.fertnstert.2020.07.050. Epub 2020 Sep 21. PMID: 32972732.

Steiner N, Shrem G, Tannus S, Dahan SY, Balayla J, Volodarsky-Perel A, Tan SL, Dahan MH. Effect of GnRH agonist and letrozole treatment in women with recurrent implantation failure. Fertil Steril. 2019 Jul;112(1):98-104. doi: 10.1016/j.fertnstert.2019.03.021. Epub 2019 May 24. PMID: 31133384.

Zhong C, Gao L, Shu L, Hou Z, Cai L, Huang J, Liu J, Mao Y. Analysis of IVF/ICSI Outcomes in Endometriosis Patients With Recurrent Implantation Failure: Influence on Cumulative Live Birth Rate. Front Endocrinol (Lausanne). 2021 Jul 30;12:640288. doi: 10.3389/fendo.2021.640288. PMID: 34393990; PMCID: PMC8362597.

Piedimonte S, Volodarsky-Perel A, Tannus S, Tan SL, Dahan MH. Pretreatment with a gonadotropin-releasing hormone agonist and an aromatase inhibitor may improve outcomes in in vitro fertilization cycles of women with stage I-II endometriosis. F S Sci. 2020 Aug;1(1):98-103. doi: 10.1016/j.xfss.2020.06.005. Epub 2020 Jul 4. PMID: 35559744.

Jaafar SH, Sallam HN, Arici A, Garcia‐Velasco JA, Abou‐Setta AM. Long‐term GnRH agonist therapy before in vitro fertilization (IVF) for improving fertility outcomes in women with endometriosis. Cochrane Database Syst Rev. 2019 Jan 8;2019(1):CD013240. doi: 10.1002/14651858.CD013240. PMCID: PMC6353287.

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Embryo Transfer Protocols: Which Protocol is Best? What Progesterone Is Best for an FET?